The Denton Island roundabout will be closed for six nights over the next fortnight while Highways England completes upgrading works.
The busy motorway roundabout closes each evening between 10pm to 6am and drivers will have to follow diversions.
The south side of the roundabout will then be closed overnight (July 14) and July 23, including the entry slip road onto the clockwise side of M60 and the exit slip road onto the anticlockwise side of the motorway.
The westbound side of the M67 will also be closed between junction 2 and the roundabout, and the westbound side of the A57 will be closed from Oldham Street to Hulme Road.
The north side of the roundabout will be closed overnight on July 15, 20, 21 and 22. This will affect the entry slip road onto the anticlockwise side of the M60.
The eastbound side of the A57 will also be closed between Hulme Road and the roundabout. The works are aimed at improving traffic flow at the junction where the M60 meets the M67 and A57.